Mass Effect 3! Predictions! (Possible Spoilers for ME1 and ME2)

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The third game will probably revolve around allegiances and building up a force strong enough to fight the entire Reaper force. Most likely, they'll have another fallback plan, like a giant construct that is a system-ending weapon.

We'll probably have more information on the rapidly-aging star Tali was studying.

Liara and Williams/Kaiden will be making a return in Mass Effect 3, and you will get rewarded if you didn't have any relationship options in ME2.

There have been many allusions to army-building in ME3.

Keeping the Genophage cure.

Encouraging/Discouraging the quarians to go to war against the geth on their homeworld.

Killing or reprogramming the Heretics in Legion's loyalty mission.

Saving the Collector Base.

Saving Wrex in the first game so he can unite the Krogan under one banner.

There will most likely be even more extreme powers you get in ME3. Given the rapid development of more powerful biotic implants, you'd probably get another implant upgrade if you're an Adept and get the power to crush a soldier into a breadbox.

Soldiers could be able to go Rambo and unleash a hellstorm of lead on the enemies. They could also get muscle upgrades to go Iron Man on the enemy and punt a Krogan 50 feet into the air and get ammo upgrades to turn all their bullets into explosive rounds.

More extreme Heavy Weapons would be fun, one that would launch balls of magma or a gigasonic-emitter that acts like a blown-up version of the biotic shockwave and just knocks everything into a wall and causes damage to their internal organs through their layers of armor. A miniaturized version of the Thatix cannon would also be sick.

It's possible we may get an SR-3 Normandy. Not that the previous Normandy was destroyed, but rather that the whole ship was rebuilt from the ground up and designed specifically to be a Reaper-killer.

We'll probably have another organization of the general bad guys to fight, and these will probably be indoctrinated by the Reapers or people who willingly side with the Reapers in a futile attempt to preserve themselves. We may also learn more about the Keepers and the innermost workings of the Citadel. And hopefully, we'll learn the true motives of the Reapers.